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KMID : 0352519950320010029
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Korea Univercity Medical Journal
1995 Volume.32 No. 1 p.29 ~ p.44
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The Biological Monitoring and Renal Response in Workers exposed to styrene
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Abstract
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Two field studies were conducted on workers exposed to low level of styrene. The objective of first study was evaluation of variations of urinary mandelic acid and phenylglyoxylic acid on 17 male-workers and 9 female-workers for 2 days, and that
of
second study was for evaluation of correlation between styrene exposure and urinary metabolites for 73 male-2orkers and 8 female-workers whose urines were sampled at end-shift and next morning.
@ES The results were as follows;
@EN 1. The mean values of urinary mandelic acid and phenylglyoxylic acid were increased as working time within 3 hours, between 4-6 hours, and between 7-9 hours elapsed.
2. The regression analysis of the urinary mandelic acid and phenylglyoxylic acid with time showed trend that urinary metabolites incresed more rapidly in higher exposure group.
3. The correlation coefficients between styrene in air ad metabolites in next morning urine were higher than those in end-shif urine. But, the correlation coefficients between styrene in air and metabolites in end-shift urine of the total
samples
were
higher than those in next morning urine of nonsmoking workers or non-drinking workers.
4. Only the stryene in air was independent variable which was statistically significant in multiple regression on urinary metabolites by styrene in air, smoking, and drinking. The slope was steeper in using the sum values of metabolites in
end-shift
urine as dependent variable than in using others. But the R square value was greater in using phenylglyoxylic acid in next morning uring as dependent variable than in using others.
5. There was no significant correlation between the styrene in air and nacetyl-β-glucosaminidase activity in urine. The smoking or drinking habit had no significant effect in the correlation.
The smoking and drinking habit would be considered in determination of time of urine sampling about urinary mandelic and phenylglyoxylic acid as biological monitoring of workers exposed to styrene. Because the correlations beween air styrene and
urinary
metabolites in next morning urine were higher than those in end-shift urine in smoking or drinking workers.
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